CANTERO LORENTE, JOSE LUIS

Jose Luis Cantero Lorente is a clinical neuroscientist with a strong background in neurobiology, brain imaging, and aging neuroscience. After obtaining my PhD degree in Neuroscience at the University of Seville (1999), I was appointed as a postdoctoral research fellow in Prof. Allan Hobson's lab at the Department of Psychiatry of Harvard University (Boston, USA), where I embarked on research aimed at studying sleep-dependent brain oscillations using intracranial EEG recordings and neuroimaging techniques. In 2003, I moved to Pablo de Olavide University (Seville, Spain) as tenure-track professor, founded the Laboratory of Functional Neuroscience (2005) and the MRI Research Unit (2015), and was promoted as Full Professor of Physiology (2018) at the Department of Physiology, Anatomy and Cell Biology. In 2008, I was appointed as Principal Investigator of the Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED). During the last fifteen years, my research has been focused on imaging markers of preclinical/prodromal Alzheimer's disease (AD), using state-of-the-art neuroimaging and neurophysiological techniques combined with cognitive and CSF/blood/saliva biomarkers. I have been the principal investigator of seventeen research grants, all of them related to biomarkers of early AD, and have published 90 research articles in renowned neuroscience journals including Nature Neuroscience, Science Advances, Journal of Neuroscience, Cerebral Cortex, Sleep Medicine Reviews, Neurobiology of Aging, Neuroimage.

Among my main scientific achievements are: i) the first evidence of state-dependent theta oscillations in the human hippocampus using intracranial EEG recordings (Cantero et al., 2003, J Neurosci); ii) in vivo MRI evidence of structural deficits of basal forebrain cholinergic compartments from preclinical (Cantero et al., 2020, Cereb Cortex) to prodromal AD (Cantero et al., 2017, Cereb Cortex; Grothe et al., 2010, Cereb Cortex); iii) the first demonstration of polysomnographic sleep alterations in mild cognitive impairment (Hita-Yañez et al., 2013, Sleep), and tau protein-related effects on sleep physiology (Cantero et al., 2010, J Alzheimer Dis); and iv) the first evidence of association between serum expression of candidate microRNAs for AD and brain imaging markers of aging vulnerability (Maldonado-Lasunción et al., 2019, Cereb Cortex; Manzano-Crespo et al., 2019, Transl Neurodegener).