Development of a reporter system for screening anti-biofilm activities

Autores/as

  • Ana Díaz-Navarro Área de Microbiología/Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide, Ctra. De Utrera, Km 1, 41013 Sevilla
  • Aroa López-Sánchez Área de Microbiología/Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide, Ctra. De Utrera, Km 1, 41013 Sevilla
  • Fernando Govantes-Romero Área de Microbiología/Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide, Ctra. De Utrera, Km 1, 41013 Sevilla

Palabras clave:

c-di-GMP; Diguanylate cyclase; Biofilm formation

Resumen

Biofilm formation is responsible for increasing antibiotic tolerance in pathogenic bacteria. It is estimated that approximately 80% of chronic infections are associated with this phenomenon. Therefore, the search for therapeutic agents with specific biofilm targets has become of vital importance. One of the main strategies is the search for enzymes that degrade the different components of the extracellular matrix. However, since the composition of the matrix varies among the different microorganisms, an alternative would be to interfere with the signaling cascades that lead to the formation of the biofilm or stimulate its dispersion.

Descargas

Los datos de descargas todavía no están disponibles.

Citas

Koo, H., Allan, R. N., Howlin, R. P., Stoodley, P., & Hall-Stoodley, L. (2017). Targeting microbial biofilms: current and prospective therapeutic strategies. NATURE REVIEWS MICROBIOLOGY, 15(12), 740.
Sambanthamoorthy, K., Luo, C., Pattabiraman, N., Feng, X., Koestler, B., Waters, C. M., & Palys, T. J. (2014). Identification of small molecules inhibiting diguanylate cyclases to control bacterial biofilm development. BIOFOULING, 30(1), 17-28.

Publicado

2020-03-19

Cómo citar

(1)
Díaz-Navarro, A.; López-Sánchez, A.; Govantes-Romero, F. Development of a Reporter System for Screening Anti-Biofilm Activities. Bs 2020.

Número

Sección

Pósteres