Publications
2007 |
Rodríguez-Baena, D.; Díaz-Díaz, N.; Aguilar-Ruiz, J.; Nepomuceno-Chamorro, I. A. Discovering alpha–Patterns from Gene Expression Data Conference Intelligent Data Engineering and Automated Learning - IDEAL 2007, 2007, ISBN: 978-3-540-77226-2. Abstract | Links | BibTeX | Tags: Gene expression analysis @conference{Rodríguez-Baena2007,The biclustering techniques have the purpose of finding subsets of genes that show similar activity patterns under a subset of conditions. In this paper we characterize a specific type of pattern, that we have called ?–pattern, and present an approach that consists in a new biclustering algorithm specifically designed to find ?–patterns, in which the gene expression values evolve across the experimental conditions showing a similar behavior inside a band that ranges from 0 up to a pre–defined threshold called ?. The ? value guarantees the co–expression among genes. We have tested our method on the Yeast dataset and compared the results to the biclustering algorithms of Cheng & Church (2000) and Aguilar & Divina (2005). Results show that the algorithm finds interesting biclusters, grouping genes with similar behaviors and maintaining a very low mean squared residue. |